产品说明
一般描述
The OPN (osteopontin) gene is mapped to mouse chromosome 5 E5 and codes for secreted phosphoprotein 1 and is mostly expressed in bone tissue.
免疫原
purified recombinant mouse osteopontin expressed in NSO cells.
生化/生理作用
Osteopontin (OPN) serves as a ligand to a number of integrin receptors which are associated with cell motility, chemotaxis, invasion and cell survival. Upregulation of OPN gene is observed in tumors such as colorectal carcinomas, breast cancer and contributes to its pathogenesis. OPN is associated with obesity by mediating adipocyte inflammation and insulin resistance upon macrophage activation. OPN functions as an effector molecule in extracellular signalling and promotes fibrosis and myocyte growth.
外形
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.
分析说明
Neutralizes the biological activity of recombinant mouse osteopontin using 293 cells.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| MDL编号 | MFCD02263865 |
| NACRES | NA.41 |
产品性质
| 质量水平 | 200 |
| 生物来源 | goat |
| 偶联物 | unconjugated |
| 抗体形式 | affinity isolated antibody |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | lyophilized powder |
| species reactivity | mouse |
| technique(s) | capture ELISA: 0.2-0.8 μg/mL immunohistochemistry: 5-15 μg/mL using mouse thymus tissue sections neutralization: 1-3 μg/mL western blot: 0.1-0.2 μg/mL |
| UniProt登记号 | P10923 |
| 储存温度 | −20℃ |
| Gene Information | mouse ... Spp1(20750) |
安全信息
| 储存分类代码 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
