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Anti-Leukemia Inhibitory Factor antibody produced in goat

品牌
Sigma-Aldrich
货号
L9277
规格纯度
IgG fraction of antiserum, lyophilized powder
参考价格
4330.86 *本价格含增值税费
促销
服务
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  • 包邮
  • 增值税票
数量
-+
产品名称:
Anti-Leukemia Inhibitory Factor antibody produced in goat
Anti-LIF
产品介绍:

产品说明

一般描述

Leukemia inhibitory factor (LIF) is a pleotrophic glycoprotein that belongs to the IL6 family of cytokines. It is secreted by many cell types such as, fibroblasts, macrophages, T cells, monocytes, liver cells, osteoblasts and cells of endometrium. LIF interacts with a heterodimeric receptor composed of two subunits, gp130 and gp190. A variety of signal transduction pathways are triggered in response to LIF including ERK/MAPK, JAK1, PI3K, STAT3, Jun-cFos and NF-κB. The various functions of LIF include proliferation of adult human T cells, maintenance of pluripotency of embryonic stem cells and inhibition of leukemic ell differentiation. Reports also indicate the important role of LIF in lactation, tissue regeneration after brain and spinal cord injury, muscle regeneration and motor neuron functions.
Anti-Leukemia Inhibitory Factor recognizes human leukemia inhibitory factor. It shows no cross-reactivity with recombinant mouse LIF.

特异性

The antibody neutralizes the biological activity of recombinant human LIF.

免疫原

recombinant human LIF expressed in E. coli

应用

Anti-Leukemia Inhibitory Factor antibody may be for immunoblotting a concentration of 1 μg/ml For ELISA a working concentration of 1 μg/ml is recommended. The antibody is suitable for neutralization reactions. For neutralization of LIF in SEK1, melanoma cell line, a concentration of 100 μg/ml was used.

外形

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline

制备说明

Purified using protein G

基本信息

MDL编号MFCD00212999
NACRESNA.41

产品性质

质量水平100
生物来源goat
偶联物unconjugated
抗体形式IgG fraction of antiserum
antibody product typeprimary antibodies
克隆polyclonal
形式lyophilized powder
species reactivityhuman
technique(s)neutralization: suitable
UniProt登记号P15018
储存温度−20℃
Gene Informationhuman ... LIF(3976)

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备Eyeshields, Gloves, type N95 (US)

Sigma-Aldrich

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