产品说明
一般描述
RB1 (RB transcriptional corepressor 1) codes for nuclear phosphoprotein pRB (retinoblastoma protein). It is located on human chromosome 13q14. It is a tumor-suppressor gene.
特异性
Recognizes Rb phosphorylated at Ser780 and does not react with non-phosphorylated Rb. Does not react with Rb phosphorylated at other sites.
免疫原
synthetic peptide corresponding to residues around pSer780 of the human retinoblastoma tumor suppressor protein (Rb).
生化/生理作用
RB1 (RB transcriptional corepressor 1) plays an important role throughout G1/S phase transition. Absence of RB induces prostate cancer metastasis. It plays an important role in modulating the cell cycle. It also regulates cell stemness and differentiation.
外形
Solution in 10 mM sodium HEPES, pH 7.5, containing 150 mM sodium chloride, 100 μg/ml bovine serum albumin, and 50% glycerol.
制备说明
Purified using protein A and affinity chromatography.
基本信息
| MDL编号 | MFCD02097166 |
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 质量水平 | 200 |
| 偶联物 | unconjugated |
| 抗体形式 | affinity isolated antibody |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous glycerol solution |
| species reactivity | human, mouse, rat |
| technique(s) | western blot (chemiluminescent): 1:1,000 using human fibroblasts synchronized by serum deprivation |
| UniProt登记号 | P06400 |
| 运输 | wet ice |
| 储存温度 | −20℃ |
| Gene Information | human ... RB1(5925) mouse ... Rb1(19645) rat ... Rb1(24708) |
Sigma-Aldrich
m.cnreagent.com
