H-GRKKRRQRRRPPQ-βA-CWMSPRHLGTC-NH2 trifluoroacetate (βA = β-alanine; C15-C25 disulfide)

产品名称：

2306481-24-1
CIGB-300 trifluoroacetate
P15-Tat trifluoroacetate
H-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Pro-Pro-Gln-βAla-Cys-Trp-Met-Ser-Pro-Arg-His-Leu-Gly-Thr-Cys-NH2 trifluoroacetate (Cys15-Cys25 disulfide)
H-GRKKRRQRRRPPQ-βA-CWMSPRHLGTC-NH2 trifluoroacetate (βA = β-alanine; C15-C25 disulfide)
CIGB-325 trifluoroacetate

产品介绍：

产品说明

生化/生理作用

CIGB-300 (P15-Tat) is a substrate-competitive casein kinase 2 inhibitor (CK2, CKII) composed of a membrane-permeant HIV-1 Tat protein transduction domain sequence (a.a. 48-60) N-terminal to a disulfide-bridged cyclic substrate peptide that inhibits against CK2-mediated substrate HPV-16 E7 phosphorylation in vitro. CIGB-300 exhibits cytotoxic effect in various cancer cultures (IC50 from 20 to 182 μM) via apoptosis induction and effectively inhibits TC-1 tumor growth in mice in vivo (48 μmol/200 μL/mouse via daily intratumoral injection).

基本信息

经验(实验)分子式	C₁₂₇H₂₁₆N₅₄O₂₉S₃
分子量	3059.61

产品性质

质量水平	100
测定	≥95% (HPLC)
形式	film
颜色	white to off-white
储存温度	−20℃