产品说明
一般描述
Inhibits thymidylate synthetase, is a nonselective de novo purine synthesis inhibitor and has a significant toxicity profile including hepatotoxicity, pneumonitis and bone marrow suppression. Potent folic acid antagonist. Induces apoptosis in HL-60 human leukemia cells. Also useful as an anti-tumor agent.
包装
1, 5 g in glass bottle
基本信息
| 经验(实验)分子式 | C20H22N8O5 |
| 分子量 | 454.44 |
| Beilstein | 70669 |
| EC 号 | 200-413-8 |
| MDL编号 | MFCD00064370 |
| PubChem化学物质编号 | 329817917 |
| NACRES | NA.21 |
产品性质
| 生物来源 | synthetic |
| 质量水平 | 400 |
| 形式 | powder |
| 适用性 | suitable for manufacturing use |
| 储存温度 | −20℃ |
| SMILES string | CN(Cc1cnc2nc(N)nc(N)c2n1)c3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O |
| InChI | 1S/C20H22N8O5/c1-28(9-11-8-23-17-15(24-11)16(21)26-20(22)27-17)12-4-2-10(3-5-12)18(31)25-13(19(32)33)6-7-14(29)30/h2-5,8,13H,6-7,9H2,1H3,(H,25,31)(H,29,30)(H,32,33)(H4,21,22,23,26,27)/t13-/m0/s1 |
| InChI key | FBOZXECLQNJBKD-ZDUSSCGKSA-N |
| Gene Information | human ... DHFR(1719) |
安全信息
| 象形图 |   |
| 警示用语： | Danger |
| 危险声明 | H301 - H315 - H319 - H341 - H360D |
| 预防措施声明 | P201 - P301 + P310 + P330 - P302 + P352 - P305 + P351 + P338 |
| 危险分类 | Acute Tox. 3 Oral - Eye Irrit. 2 - Muta. 2 - Repr. 1B - Skin Irrit. 2 |
| 储存分类代码 | 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects |
| WGK | WGK 3 |
Sigma-Aldrich
m.cnreagent.com
