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Cyclosporin A, Ready Made Solution

环孢霉素

品牌
Sigma-Aldrich
CAS
59865-13-3
货号
SML1018
包装型号
规格纯度
1 mg/mL in DMSO
参考价格
1824.59 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
59865-13-3
Cyclosporin A, Ready Made Solution
Cyclosporine
CSA
环孢霉素
产品介绍:

产品说明

应用

Cyclosporin A has been used to test its toxic effect on perfused 3D proximal tubule model.

生化/生理作用

Cyclosporin A is a non-polar cyclic oligopeptide produced by the fungus Tolypocladium inflatum. It is a potent immunosuppressive agent, affecting primarily T-lymphocytes. It has been shown to inhibit the functioning of several nuclear proteins involved in T-cell activation at the level of mRNA transcription. It forms a complex with its intracellular receptor cyclophilin, which can then bind to calcineurin, a Ca2+- and calmodulin-dependent protein phosphatase, inhibiting its enzymatic activity. CsA was found to suppress the replication of hepatitis C virus genome in cultured hepatocytes. At concentrations >10 nM, CsA protected isolated hepatocytes against the action of phalloidin. CsA can inhibit IL2 production resulting from T cell activation via Calcineurin inhibition.
An extensive list of references has been reported, including a comprehensive review of analytical properties.
Cyclosporin A is generally given subsequent to transplant surgery to prevent rejection. In addition to its beneficial effects in organ transplantation, cyclosporin (CyA) exhibits nephrotoxic side effects.

其他说明

Light sensitive

基本信息

经验(实验)分子式C62H111N11O12
分子量1202.61
EC 号200-664-3
NACRESNA.77

产品性质

形式DMSO solution
质量水平200
储存条件protect from light
浓度1 mg/mL in DMSO
运输dry ice
储存温度−20℃
InChI1S/C62H111N11O12/c1-25-27-28-40(15)52(75)51-56(79)65-43(26-2)58(81)67(18)33-48(74)68(19)44(29-34(3)4)55(78)66-49(38(11)12)61(84)69(20)45(30-35(5)6)54(77)63-41(16)53(76)64-42(17)57(80)70(21)46(31-36(7)8)59(82)71(22)47(32-37(9)10)60(83)72(23)50(39(13)14)62(85)73(51)24/h25,27,34-47,49-52,75H,26,28-33H2,1-24H3,(H,63,77)(H,64,76)(H,65,79)(H,66,78)/b27-25+
InChI keyPMATZTZNYRCHOR-IMVLJIQESA-N

安全信息

储存分类代码10 - Combustible liquids
WGKWGK 1
闪点(F)188.6 °F - closed cup
闪点(C)87 ℃ - closed cup

Sigma-Aldrich

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