您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 品牌 > Sigma-Aldrich > Kininogen high molecular weight, Two Chain 来源于人类血浆

Kininogen high molecular weight, Two Chain from human plasma

Kininogen high molecular weight, Two Chain 来源于人类血浆

品牌
Sigma-Aldrich
货号
K1632
规格纯度
lyophilized powder
参考价格
1220.09 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
Kininogen high molecular weight, Two Chain from human plasma
Kininogen high molecular weight, Two Chain 来源于人类血浆
产品介绍:

产品说明

一般描述

HK (KNG1) gene is mapped to human chromosome 3q27.3. It is a glycoprotein.
High-molecular-weight kininogen (HK) is the substrate and cofactor of the plasma kallikrein-kinin system (KKS). It is present at a concentration of 660 nM on the plasma and binds to platelet GPI-V-IX complex.

生化/生理作用

High-molecular-weight kininogen (HK) inhibits binding of thrombin to platelets.
High molecular weight kininogen, two chain, is a participant in contact phase activation of the intrinsic blood coagulation cascade that forms a substrate on which blood factor XI is held in proximity to factor XII allowing reciprocal activation of the two factors. It is also involved in the activation of prekallikrein. High molecular weight kininogen binds to proteoglycans on the surface of platelets, endothelial cells, and other cell types. Domain 5 of high molecular weight kininogen inhibits platelet aggregation and angiogenesis.

包装

Package size based on protein content

外形

Lyophilized from 4 mM sodium acetate, pH 5.3, 0.15 M NaCl

制备说明

Prepared by kallikrein digestion of human kininogen. Purified to remove kallikrein and kinin.

基本信息

MDL编号MFCD00131428
NACRESNA.61

产品性质

质量水平200
生物来源human plasma
形式lyophilized powder
溶解性H2O: soluble 0.1 mg protein/mL
UniProt登记号P01042
储存温度−20℃
Gene Informationhuman ... KNG1(3827), KNG1 (includes EG:3827)(3827)

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备Eyeshields, Gloves, type N95 (US)

Sigma-Aldrich

推荐产品