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位置:首页 > 品牌 > Sigma-Aldrich > Monoclonal Anti-Human IgM (μ-chain specific)-Peroxidase antibody produced in mouse

Monoclonal Anti-Human IgM (μ-chain specific)-Peroxidase antibody produced in mouse

品牌
Sigma-Aldrich
货号
SAB4200748
规格纯度
clone MB-11, purified immunoglobulin
参考价格
6123.61 *本价格含增值税费
促销
服务
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  • 包邮
  • 增值税票
数量
-+
产品名称:
Monoclonal Anti-Human IgM (μ-chain specific)-Peroxidase antibody produced in mouse
Anti-Human immunoglobulin M
产品介绍:

产品说明

一般描述

Monoclonal Anti-Human IgM (mouse IgG2b isotype) is derived from the MB-11 hybridoma, produced by the fusion of mouse myeloma cells and splenocytes from a BALB/c mouse immunized with purified human IgM protein. Immunoglobulin M (IgM) is the major class of surface immunoglobulins on lymphocytes membranes. IgM has a pentameric structure, in which monomers are linked together via disulfide bonds. Surface IgM is expressed on immature and mature B cells, whereas IgM heavy chain is expressed intracellularly in pre-B cells. IgM serves as the antigen receptor of naive B cells.

特异性

Monoclonal Anti-Human IgM (μ-chain) specifically recognizes μ chain of Human IgM. The antibody shows no cross-reactivity with human IgG, Fab, Fc, kappa, lambda and gamma chains.

免疫原

purified human IgM protein

应用

Monoclonal Anti-Human IgM (μ-chain specific)-Peroxidase antibody produced in mouse may suitable for use in enzyme-linked immunosorbent assay (ELISA).

生化/生理作用

IgM is suggested to act as the first line of defense during microbial infections. Secreted IgM (sIgM) is involved in B cell maturation and complement activation. Detection of IgM antibodies in a patient′s serum may indicates a recent infection and IgM in a neonate′s serum may indicate on intrauterine infection (e.g. congenital rubella syndrome). In addition, the development of anti-donor IgM after combined liver-kidney transplantation has been shown to provide a graft- protecting effect. Anti-Human IgM (μ-specific) antibodies can be used in detection of the abnormal concentration of IgM in patient sera and IgM-associated pathologies, such as selective IgM immunodeficiency (SIgMD) and the hyperimmunoglobulin M (hyper-IgM or HIGM) syndromes.

外形

Supplied as a lyophilized powder

储存及稳定性

Store the lyophilized product at 2–8 ℃. For extended storage after reconstitution, keep at –20 ℃ in working aliquots. Avoid repeated freeze-thaw cycles. For continuous use after reconstitution, keep at 2–8 ℃ for up to 1 month. Solutions at working dilution should be discarded if not used within 12 hours.

免责声明

Unless otherwise stated in our catalog, our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRESNA.46

产品性质

质量水平200
生物来源mouse
偶联物peroxidase conjugate
抗体形式purified immunoglobulin
antibody product typeprimary antibodies
克隆MB-11, monoclonal
形式lyophilized powder
species reactivityhuman
浓度~2.0 mg/mL
technique(s)ELISA: 1:40,000-1:80,000 using 2.5 μg/mL Human IgM for coating
同位素/亚型IgG2b
运输dry ice
储存温度−20℃

安全信息

象形图GHS07
警示用语:Warning
危险声明H317
预防措施声明P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364
危险分类Skin Sens. 1
储存分类代码12 - Non Combustible Liquids
WGKWGK 2
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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