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NF-κB Activation Inhibitor-CAS 545380-34-5-Calbiochem

品牌
Sigma-Aldrich
CAS
545380-34-5
货号
481406
规格纯度
The NF-κB Activation Inhibitor, also referenced under CAS 545380-34-5, controls the biological activity of NF-κB. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.
参考价格
1903.37 *本价格含增值税费
促销
服务
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  • 包邮
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数量
-+
产品名称:
545380-34-5
NF-κB Activation Inhibitor-CAS 545380-34-5-Calbiochem
6-Amino-4-(4-phenoxyphenylethylamino)quinazoline
产品介绍:

产品说明

一般描述

A cell-permeable quinazoline compound that acts as a highly potent inhibitor of NF-κB transcriptional activation (IC50 = 11 nM in Jurkat cells) and LPS-induced TNF-α production (IC50 = 7 nM in murine splenocytes). Shown to exhibit anti-inflammatory effect on carrageenin-induced paw edema in rat. A 10 mM (1 mg/281 µl) solution of NF-κB Activation Inhibitor (Cat. No. 481407) in DMSO is also available.
A cell-permeable quinazoline compound that acts as a potent inhibitor of NF-κB transcriptional activation (IC50 = 11 nM in Jurkat cells) and LPS-induced TNF-α production (IC50 = 7 nM in murine splenocytes). Does not exhibit cellular cytotoxicity even at concentrations as high as 10 µM. Reported to exhibit anti-inflammatory effects on carregeenin-induced paw edema in rats.

包装

1 mg in Plastic Bag(s)
Packaged under inert gas

生化/生理作用

Product does not compete with ATP.
Cell permeable: yes
Primary Target
NF-κB transcriptional activation
Reversible: no
Target IC50: 11 nM against NF-κB transcriptional activation in Jurkat cells

警告

Toxicity: Toxic (F)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Tobe, M., et al. 2003. Bioorg. Med. Chem.11, 383.
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C22H20N4O
分子量356.42
MDL编号MFCD06411436

产品性质

质量水平100
测定≥98% (HPLC)
形式solid
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
protect from light
颜色 off-white
溶解性DMSO: 5 mg/mL
运输ambient
储存温度2-8℃

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3

Sigma-Aldrich

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