Z-Ile-Glu(O-ME)-Thr-Asp(O-Me) fluoromethyl ketone

产品名称：

220760-26-9
Z-Ile-Glu(O-ME)-Thr-Asp(O-Me) fluoromethyl ketone
Z-IETD-FMK

产品介绍：

产品说明

Amino Acid Sequence

Z-Ile-Glu-OMe-Thr-Asp-OMe-FMK

应用

Z-Ile-Glu(O-ME)-Thr-Asp(O-Me) fluoromethyl ketone (Z-IETD-FMK) has been used as a caspase-8 inhibitor:

to study the activity of caspase-8 in porcine kidney cells
to study its effects on porcine parvovirus (PPV)-induced caspase-3 activity in steroidogenic luteal cells
to study its effects on retinal ganglion and astroglia in rat eyes

生化/生理作用

Z-Ile-Glu(O-ME)-Thr-Asp(O-Me) fluoromethyl ketone (Z-IETD-FMK) is an irreversible and cell-permeable caspase-8 inhibitor.

特点和优势

This compound is featured on the Caspases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

基本信息

经验(实验)分子式	C₃₀H₄₃FN₄O₁₁
分子量	654.68
MDL编号	MFCD01861686
PubChem化学物质编号	329774744
NACRES	NA.77

产品性质

质量水平	200
生物来源	synthetic (organic)
测定	≥90% (TLC)
形式	powder
溶解性	methanol: 10 mg/mL DMSO: 20 mM, clear, colorless to light yellow
运输	dry ice
储存温度	−20℃
SMILES string	CC[C@H](C)[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)O)C(=O)N[C@@H](CC(O)=O)C(=O)CF
InChI	1S/C28H39FN4O11/c1-4-15(2)23(33-28(43)44-14-17-8-6-5-7-9-17)26(41)30-18(10-11-21(36)37)25(40)32-24(16(3)34)27(42)31-19(12-22(38)39)20(35)13-29/h5-9,15-16,18-19,23-24,34H,4,10-14H2,1-3H3,(H,30,41)(H,31,42)(H,32,40)(H,33,43)(H,36,37)(H,38,39)/t15-,16+,18-,19-,23-,24-/m0/s1
InChI key	CTXDBLYOEUERAT-VUVYEONESA-N

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Gloves, type N95 (US)