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7-keto-27-hydroxycholesterol

品牌
Avanti
CAS
240129-30-0
货号
700022P
规格纯度
3β,27-dihydroxy-5-cholesten-7-one, powder
参考价格
2854.09 *本价格含增值税费
促销
服务
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数量
-+
产品名称:
240129-30-0
7-keto-27-hydroxycholesterol
产品介绍:

产品说明

一般描述

7-keto-27-hydroxycholesterol interconversion to 7β,(25R)26-dihydroxycholesterol (7β,26-diHC) is catalyzed by hydroxysteroid 11-β dehydrogenase. It is also formed by the oxidation of 7-oxocholesterol (7-OC) in the presence of enzyme by sterol 26-hydroxylase (CYP27A1).

应用

7-keto-27-hydroxycholesterol has been used as an oxysterol compound to study its interaction with smoothened (SMO) protein, as a substrate to 11β-hydroxysteroid dehydrogenases (11β-HSDs) for kinetic measurement studies,

生化/生理作用

7-keto-27-hydroxycholesterol (7-OC) acts as an agonist for the smoothened (SMO) protein of Hedgehog (Hh) signalling pathway, which is vital for proper cell differentiation in embryonic tissue. It elicits strong affinity to SMO compared to 7β,(25R)26-dihydroxycholesterol (7β,26-diHC). 7-OC is reduced to 7β,(25R)26-dihydroxycholesterol (7β,26-diHC) by reactive oxygen species (ROS).

包装

5 mL Amber Glass Screw Cap Vial (700022P-1mg)

基本信息

经验(实验)分子式C27H44O3
分子量416.64
NACRESNA.25

产品性质

测定>99% (TLC)
形式powder
包装pkg of 1 × 1 mg (700022P-1mg)
manufacturer/tradenameAvanti Polar Lipids 700022P
运输dry ice
储存温度−20℃

安全信息

储存分类代码13 - Non Combustible Solids

Sigma-Aldrich

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