人骨保护素/ TNFRSF11b ELISA试剂盒

产品名称：

Human Osteoprotegerin / TNFRSF11b ELISA Kit
OPG
人骨保护素/ TNFRSF11b ELISA试剂盒

产品介绍：

产品说明

一般描述

The Human Osteoprotegerin ELISA (Enzyme-Linked Immunosorbent Assay) kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of human Osteoprotegerin in serum, plasma, cell culture supernatants and urine.
Osteoprotegerin (OPG) is encoded by the gene mapped to human chromosome 8q24. It is a member of the TNFR (tumor necrosis factor receptor) superfamily that can act as a decoy receptor for RANKL (receptor activator of nuclear factor kappa-B ligand) and TRAIL (tumor necrosis factor-related apoptosis-inducing ligand). OPG is expressed in a wide variety of tissues, including adult heart, lung, kidney and liver. It is secreted both as a monomeric and a dimeric protein.

免疫原

Recombinant Human OPG

应用

请参考Protocol了解详情。

生化/生理作用

Binding of soluble osteoprotegerin (OPG) to sRANKL (soluble receptor activator of nuclear factor κ-B ligand) inhibits osteoclastogenesis by interrupting the signaling between stromal cells and osteoclastic progenitor cells. This process leads to excess accumulation of bone and cartilage. Changes in the level of serum OPG are associated with atherosclerosis and cardiovascular disorders(CVDs). It might also be associated with malignancy and plays a regulatory role in multiple myeloma, prostate, breast, bladder and gastric carcinoma. OPG plays a vital role in bone metabolism and is involved in inhibition of ovariectomy-associated bone loss in rats. It is also used as a potent biomarker for CVD.

其他说明

A sample Certificate of Analysis is available for this product.
Please type the word sample in the text box provided for lot number.

基本信息

NACRES

NA.32

产品性质

species reactivity	human
包装	kit of 96 wells (12 strips x 8 wells)
technique(s)	ELISA: suitable capture ELISA: suitable
input	sample type serum sample type plasma sample type urine sample type cell culture supernatant(s)
assay range	inter-assay cv: <12% intra-assay cv: <10% sensitivity: 1 pg/mL standard curve range: 1.23-900 pg/mL
detection method	colorimetric
运输	wet ice
储存温度	−20℃
Gene Information	human ... TNFRSF11B(4982)

组份列表

组份可单独销售

货号	组份
RABELADA	ELISA 1X Assay/Sample Diluent Buffer A (Item D1)
RABELADB	ELISA 5X Assay/Sample Diluent Buffer B (Item E1)
RABSTOP3	ELISA Stop Solution (Item I)
RABTMB3	ELISA Colorimetric TMB Reagent (HRP Substrate, Item H)
RABWASH4	20X Wash Buffer (Item B)

安全信息

象形图
警示用语：	Warning
危险声明	H290
预防措施声明	P234 - P390
危险分类	Met. Corr. 1
储存分类代码	8A - Combustible, corrosive hazardous materials
WGK	WGK 3