产品说明
一般描述
Urokinase (Urokinase-type plasminogen activator, uPA, EC 3.4.21.73) is a serine protease involved in the degradation of extracellular matrix components. It cleaves the Arg-Val bond in plasminogen and converts it to plasmin. The activity of uPA is important in tumor cell proliferation and migration. Polymorphisms in uPA gene are reportedly associated with Alzheimer′s disease.
适用性
适于筛选尿激酶抑制剂。
原理
The Urokinase Inhibitor Screening Kit is a rapid, simple and sensitive assay that is suitable for the screening of Urokinase inhibitors. Urokinase activity is measured by cleaving a synthetic 7-amino-4-trifluoromethylcoumarin (AFC)-based substrate to yield AFC, a fluorescent product (λex = 350/ λem = 450 nm), proportional to the enzymatic activity present.
基本信息
| NACRES | NA.25 |
产品性质
| detection method | fluorometric |
| 储存温度 | −20℃ |
| Gene Information | human ... PLAU(5328) mouse ... PLAU(18792) rat ... PLAU(25619) |
组份列表
组份不可单独销售
| 货号 | 组份 |
| Urokinase Assay Buffer | |
| Urokinase Substrate | |
| Human Urokinase | |
| Urokinase Inhibitor; 10 mM GGACK Dihydrochloride |
安全信息
| 象形图 |  |
| 警示用语： | Danger |
| 危险声明 | H334 |
| 预防措施声明 | P261 - P284 - P501 |
| 危险分类 | Resp. Sens. 1 |
| 储存分类代码 | 10 - Combustible liquids |
| WGK | WGK 3 |
Sigma-Aldrich
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