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Furin Inhibitor I-Calbiochem

弗林蛋白酶抑制剂 I-Calbiochem

品牌
Sigma-Aldrich
货号
344930
规格纯度
Furin Inhibitor I, is a peptidyl chloromethylketone that binds to the catalytic site of furin and blocks its activity.
参考价格
2950.71 *本价格含增值税费
促销
服务
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  • 包邮
  • 增值税票
数量
-+
产品名称:
Furin Inhibitor I-Calbiochem
Decanoyl-RVKR-CMK
弗林蛋白酶抑制剂 I-Calbiochem
产品介绍:

产品说明

一般描述

A peptidyl chloromethylketone that binds to the catalytic site of furin and blocks its activity. Hence, it can be used as a high specificity cleavage inhibitor of viral glycoproteins and blocker of viral replication. Reported to block the shedding of MT5-MMP by furin and prevent the activation of MT5-MMP. Also shown to reduce the pro-peptide cleavage of BACE (β-site APP-cleaving enzyme).
A peptidyl chloromethylketone that binds irreversibly to the catalytic site of furin and blocks its activity. Hence, it can be used as a high specificity cleavage inhibitor of viral glycoproteins and blocker viral replication. Reported to block the shedding of MT5-MMP by furin and prevent the activation of MT5-MMP. Completely inhibits the cleavage of Boc-RVRR-AMC (50 µM) by purified furin or PACE4. Also inhibits the activity of endothelin converting enzyme and reduces the pro-peptide cleavage of BACE (β-site APP-cleaving enzyme).

包装

1 mg in Plastic ampoule

生化/生理作用

Cell permeable: yes
Product does not compete with ATP.
Reversible: no
Primary Target
viral glycoproteins

警告

Toxicity: Standard Handling (A)

序列

Decanoyl-Arg-Val-Lys-Arg-CMK

外形

Supplied as a trifluoroacetate salt.

重悬

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

其他说明

Sugrue, R.J., et al. 2001. J. Gen. Virol.82, 1375.
Wang, X., and Pei, D. 2001. J. Biol. Chem.276, 35953.
Capell, A., et al. 2000. J. Biol. Chem. 275, 30849.
Denault, J.B., et al. 1995. FEBS Lett. 362, 276.
Denault, J.B., et al. 1995. J. Cardiovasc. Pharmacol.26, S47.
Garten, W., et al. 1994. Biochimie 76, 217.
Hallenberger, S., et al. 1992. Nature 360, 358.
Stieneke-Gröber, A., et al. 1992. EMBO J. 11, 2407.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C34H66ClN11O5
分子量744.41

产品性质

质量水平100
测定≥90% (HPLC)
形式solid
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
desiccated
颜色 off-white
溶解性methanol: 1 mg/mL
DMSO: soluble
运输ambient
储存温度−20℃

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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