Monoclonal Anti-CD38 antibody produced in mouse

产品说明

一般描述

The antibody HIT2 reacts with CD38 (T10), a 45 kDa type II transmembrane glycoprotein strongly expressed mainly on plasma cells and activated T and B lymphocytes; it is an antigenic marker of lymphoid cells.

免疫原

Human thymocytes in foetus

应用

The reagent is designed for Flow Cytometry analysis. Suggested working dilution for Flow Cytometry is 2-8 μg/mL of sample. Indicated dilution is recommended starting point for use of this product. Working concentrations should be determined by the investigator.

生化/生理作用

Cluster of differentiation 38 (CD38) controls the release of oxytocin hormone that regulates social cognition and affiliative behaviors. CD38 serves as a receptor, an ectoenzyme and acts as a highly conserved calcium-signaling molecule while functioning as a secondary messenger. The generation of cyclic Adenosine diphosphate-ribose and nicotinic acid adenine dinucleotide phosphate from NAD⁺ and NAD phosphate by ADP-ribosyl cyclase is catalyzed by CD38. The formation of adenosine is an important function of CD38. The pleiotropic nucleoside adenosine formed, acts as a regulator of immune functions and inflammation process.

特点和优势

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外形

Solution in phosphate buffered saline, pH 7.4, with 15 mM sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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