产品说明
一般描述
Each vial contains 1 μmole of purified desmosine.
应用
Desmosine chloride is often used in assays for free or urinary desmosine as markers for disease states characterized by elastin degradation (e.g., emphysema). Elastin degradation has shown strong correlation with vascular calcification, and pretreatment with aluminum ions can inhibit the binding of matrix metalloproteinase (MMP) to elastin.
Assays for free or urinary desmosine are often used as markers for disease states characterized by elastin degradation (e.g., emphysema). Conversely, excessive levels of incorporated desmosine are indicators of fibrotic conditions (e.g., cirrhosis).
生化/生理作用
Desmosine is a polyfunctional amino acid that forms cross-links in mature elastin.
注意
极易吸湿
分析说明
Calibrated by UV and amino acid analysis.
基本信息
| 经验(实验)分子式 | C24H40ClN5O8 |
| 分子量 | 562.06 |
| MDL编号 | MFCD12910449 |
| PubChem化学物质编号 | 329798901 |
| NACRES | NA.56 |
产品性质
| 质量水平 | 100 |
| 生物来源 | bovine |
| 测定 | 99.5%±0.2% |
| 形式 | lyophilized powder |
| 纯化方式 | chromatography (and purified by solvent extraction) |
| 储存温度 | 2-8℃ |
| SMILES string | [Cl-].NC(CCCC[n+]1cc(CCC(N)C(O)=O)c(CCCC(N)C(O)=O)c(CCC(N)C(O)=O)c1)C(O)=O |
| InChI | 1S/C24H39N5O8.ClH/c25-17(21(30)31)5-1-2-11-29-12-14(7-9-19(27)23(34)35)16(4-3-6-18(26)22(32)33)15(13-29)8-10-20(28)24(36)37;/h12-13,17-20H,1-11,25-28H2,(H3-,30,31,32,33,34,35,36,37);1H |
| InChI key | FUPMLZCXPJSGPV-UHFFFAOYSA-N |
安全信息
| 储存分类代码 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
| 个人防护装备 | Eyeshields, Gloves, type N95 (US) |
Sigma-Aldrich
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