SB 203580, Hydrochloride-CAS 869185-85-3-Calbiochem

产品名称：

869185-85-3
SB 203580, Hydrochloride-CAS 869185-85-3-Calbiochem
4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)1H-imidazole, HCl, p38 MAP Kinase Inhibitor XVI, Hydrochloride

产品介绍：

产品说明

一般描述

A water-soluble form of the potent MAP kinase inhibitor SB 203580 (Cat. No. 559389).
A water-soluble form of the potent MAP kinase inhibitor SB 203580 (Cat. No. 559389).

包装

1, 10 mg in Plastic ampoule

生化/生理作用

Cell permeable: yes
Product does not compete with ATP.
Reversible: no
Primary Target
p38 MAP kinase
Target IC₅₀: 34 nM against p38 MAP kinase in vitro, 600 nM in cells; 50-100 nM against IL-1 and TNF-a production from LPS-stimulated human monocytes and the human monocyte cell line THP-1; 0.2-1.0 µM against platelet aggregation caused by collagen

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C₂₁H₁₆FN₃OS · xHCl
分子量	377.43 (free base basis)

产品性质

质量水平	100
测定	≥95% (HPLC)
形式	solid
manufacturer/tradename	Calbiochem^®
储存条件	OK to freeze desiccated (hygroscopic) protect from light
颜色	bright yellow
溶解性	water: 10 mg/mL DMSO: soluble
运输	ambient
储存温度	−20℃

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3