Bisindolylmaleimide I, Hydrochloride-CAS 176504-36-2-Calbiochem

产品说明

一般描述

A reversible and ATP-competitive inhibitor of protein kinase C (K_i = 10 nM). Inhibits protein kinase A at much higher concentrations (K_i = 2 µM). An enhanced water soluble form of Bisindolylmaleimide I (Cat. No. 203290).
An enhanced water-soluble form of Bisindolylmaleimide I (Cat. No. 203290). A reversible and ATP-competitive inhibitor of protein kinase C (K_i = 10 nM). May inhibit protein kinase A at much higher concentrations (K_i = 2 µM).

包装

1 mg in Plastic ampoule
250 μg in Plastic ampoule

生化/生理作用

Target K_i: 10 nM against protein kinase C
Primary Target
Protein kinase C
Product competes with ATP.
Cell permeable: no
Reversible: yes

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C.

其他说明

Le Panse, R., et al. 1994. Mol. Pharmacol.46, 445.
Kuchera, S., et al. 1993. Agents Actions 39, C169.
Wilkinson, S.E., et al. 1993. Biochem. J.294, 335.
Toullec, D., et al. 1991. J. Biol. Chem. 266, 15771.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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