产品说明
生化/生理作用
Novobiocin, a member of aminocoumarin antibiotics, is naturally produced by Streptomyces niveus. Novobiocin is a well-known inhibitor of bacterial DNA gyrase and mammalian topoisomerase, ATP-dependent enzymes involved in cell division. It can be used in cell culture systems to treat mycoplasma contaminations. Furthermore, Novobiocin has an anti-cancer effects through Hsp90 (heat shock protein) inhibition., In addition, novobiocin shows a minimum inhibitory effect 0.25-16 μg/mL against gram positive and negative bacteria.
制备说明
Novobiocin Ready Made Solution is light sensitive. Thaw this product at room temperature. It is recommended to avoid repeated freeze thaw cycles of this product. The suggested concentration of Novobiocin for cell culture assays is 50-1000 μg/mL,,, therefore, it is recommended to dilute the Ready Made Solution 1:100-2000.
基本信息
| 线性分子式 | C31H35N2NaO11 |
| 分子量 | 634.61 |
产品性质
| 生物来源 | microbial |
| 测定 | ≥90% |
| 形式 | liquid |
| 浓度 | 100 mg/mL in water (0.2μm filtered) |
| 作用机制 | DNA synthesis | interferes enzyme | inhibits |
| 抗生素抗菌谱 | Gram-negative bacteria Gram-positive bacteria mycobacteria neoplastics |
| 储存温度 | −20℃ |
安全信息
| 象形图 |  |
| 警示用语： | Warning |
| 危险声明 | H317 |
| 预防措施声明 | P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364 |
| 危险分类 | Skin Sens. 1 |
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
