Ac-rCEHfRWC-NH<SUB>2</SUB>, TFA (D-amino acids in lower case; C2→C8 disulfide)

产品名称：

819048-44-7
LY2112688 trifluoroacetate
LY-2112688 TFA salt
Ac-D-Arg-c(Cys-Glu-His-D-Phe-Arg-Trp-Cys)-NH2, trifluoroacetate salt
Ac-D-Arg-cyclo[Cys-Glu-His-D-Phe-Arg-Trp-Cys]-NH2, trifluoroacetate salt
Ac-rCEHfRWC-NH₂, TFA (D-amino acids in lower case; C2→C8 disulfide)
Acetyl-D-Arg-Cys-Glu-His-D-Phe-Arg-Trp-Cys-NH2, trifluoroacetate salt (Cys2→Cys8 disulfide)
LY 2112688 TFA salt

产品介绍：

产品说明

生化/生理作用

LY2112688 is a beta-melanocyte-stimulating hormone (β-MSH)-derived peptide that acts as a high-affinity, potent and selective melanocortin receptor 4 (MC-4, MC-4R, MC4-R, MC4R) agonist (human/rat MC-4 Ki = 0.55/0.39 nM; human MC-1/3/5 Ki = 16.78/56.79/>500 nM). LY2112688 selectively induces MC-4-mediated cAMP release (MC-4/3 EC50 = 0.25 nM/1.61 nM, MC-4/3 Emax = 94.5%/84.1% of NDP-α-MSH Emax using HEK293 expressing respective human receptors) and exhibits in vivo efficacy in reducing daily food intake and promoting weight loss among diet-induced obese rats (75 & 299 nmol/kg/day s.c.).

基本信息

经验(实验)分子式	C₅₁H₇₀N₁₈O₁₁S₂ · xC₂HF₃O₂
分子量	1175.35 (free base basis)

产品性质

质量水平	100
测定	≥95% (HPLC)
形式	lyophilized powder
颜色	white to off-white
储存温度	−20℃

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable