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7DG

品牌
Sigma-Aldrich
CAS
26927-01-5
货号
SML0806
规格纯度
≥95% (HPLC)
参考价格
702.02 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
26927-01-5
7DG
7-Desacetoxy-6,7-dehydrogedunin
产品介绍:

产品说明

一般描述

7-Desacetoxy-6,7-dehydrogedunin (7DG) is structurally similar to HSP90 (heat shock protein 90) inhibitor, also known as gedunin.

包装

1, 5 mg in glass bottle

生化/生理作用

7-Desacetoxy-6,7-dehydrogedunin (7DG) is a selective inhibitor of protein kinase R (PKR). 7DG appears to directly interact with the C-terminal half of PKR, and unlike C16, does not bind the ATP catalytic pocket. 7-Desacetoxy-6,7-dehydrogedunin completely protected macrophages from anthrax lethal toxin (LT)-induced pyroptotic cell death, a model for inflammasome-mediated caspase-1 activation, with an (IC50) of 5 μM, showing a role for PKR in pyroptosis.

特点和优势

This compound is featured on the Caspases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

基本信息

经验(实验)分子式C26H30O5
分子量422.51
NACRESNA.77

产品性质

质量水平100
测定≥95% (HPLC)
形式powder
颜色 white to beige
溶解性DMSO: 5 mg/mL, clear
运输wet ice
储存温度2-8℃

安全信息

象形图GHS07
警示用语:Warning
危险声明H302
危险分类Acute Tox. 4 Oral
储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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