Gly-Arg-Gly-Asp-Ser-Pro-Lys

产品名称：

111119-28-9
Gly-Arg-Gly-Asp-Ser-Pro-Lys
GRGDSPK

产品介绍：

产品说明

Amino Acid Sequence

Gly-Arg-Gly-Asp-Ser-Pro-Lys

一般描述

Gly-Arg-Gly-Asp-Ser-Pro-Lys is a RGD peptide. Naturally occurring RGD peptides, present in the ECM (extracellalar matrix) proteins, are involved in facilitating integrin-mediated cell adhesion to matrix proteins. RGD peptide is present as repeats in cell-adhesion protein, such as fibronectin and vitronectin. This tripeptide is recognized by cells by specific integrins (e.g. β1 , β3 , and β5 subunits), present on the cell surface and associated with the actin filament via the FA (focal adhesion)-complex.

应用

Gly-Arg-Gly-Asp-Ser-Pro-Lys (RGD peptide) has been used-

as a blocking peptide to inhibit integrin-fibronectin binding
in adhesion assay performed on porcine trophectoderm to study the influence of TGFβ (transforming growth factor) on cell adhesion
for incubation of MC3T3-E1 osteoblast cells to determine its effect on cell adhesion measured by AFM (atomic force microscopy)
for the preparation of RGD.Flt23k.NR nanoparticles
to determine the involvement of RGD-integrin bonding in cell adhesion process

生化/生理作用

Fibronectin analog that binds to integrins.

基本信息

经验(实验)分子式	C₂₈H₄₉N₁₁O₁₁
分子量	715.76
MDL编号	MFCD00076462
PubChem化学物质编号	24895055
NACRES	NA.32

产品性质

质量水平	200
生物来源	human
测定	≥97% (HPLC)
形式	powder
technique(s)	blocking: suitable ligand binding assay: suitable
储存温度	−20℃
SMILES string	NCCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](CCCNC(N)=N)NC(=O)CN)C(O)=O
InChI	1S/C28H49N11O11/c29-8-2-1-5-16(27(49)50)37-25(47)19-7-4-10-39(19)26(48)18(14-40)38-24(46)17(11-22(43)44)36-21(42)13-34-23(45)15(35-20(41)12-30)6-3-9-33-28(31)32/h15-19,40H,1-14,29-30H2,(H,34,45)(H,35,41)(H,36,42)(H,37,47)(H,38,46)(H,43,44)(H,49,50)(H4,31,32,33)/t15-,16-,17-,18-,19-/m0/s1
InChI key	ZRVZOBGMZWVJOS-VMXHOPILSA-N
Gene Information	human ... ITGA2B(3674), ITGAV(3685)

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Gloves, type N95 (US)