产品说明
包装
1, 5, 10 mg in glass bottle
生化/生理作用
Sp-Diastereomer of adenosine 3′,5′-cyclic monophosphorothioate is a potent, membrane-permeable activator of cAMP dependent protein kinase I and II that mimics the effects of cAMP as a second messenger in numerous systems while being resistant to cyclic nucleotide phosphodiesterases; exhibits greater specificity and affinity than forskolin and cAMP analogs such as dibutyryl-cAMP.
基本信息
| 经验(实验)分子式 | C10H11N5O5PS · C6H16N · xH2O |
| 分子量 | 446.46 (anhydrous basis) |
| MDL编号 | MFCD01459901 |
| PubChem化学物质编号 | 24890576 |
| NACRES | NA.77 |
产品性质
| 质量水平 | 100 |
| 测定 | ≥98% (HPLC) |
| 形式 | solid |
| 旋光性 | [α]22/D −25.43°, c = 0.99 in H2O(lit.) |
| 颜色 | white |
| 溶解性 | H2O: soluble |
| web metadata keyword.default | Sp-3′,5′-cAMPS; A166; cAMPS-Sp; Sp-cAMPS; Adenosine 3′,5′-Cyclic-monophosphothioate, Sp-Isomer; phosphothioate; cAMP analogue; axial exocyclic; diastereomer; stereoselective agonist; stereoselective antagonist; camp dependent kinase; camp dependent protein kinase; forskolin; DBcAMP; dibutyryl |
| 储存温度 | −20℃ |
| SMILES string | CCN(CC)CC.Nc1ncnc2n(cnc12)[C@@H]3O[C@@H]4CO[P@@](S)(=O)O[C@H]4[C@H]3O |
| InChI | 1S/C10H12N5O5PS.C6H15N/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7-4(19-10)1-18-21(17,22)20-7;1-4-7(5-2)6-3/h2-4,6-7,10,16H,1H2,(H,17,22)(H2,11,12,13);4-6H2,1-3H3/t4-,6-,7-,10-,21+;/m1./s1 |
| InChI key | OXIPZMKSNMRTIV-BIQAKYJPSA-N |
安全信息
| 储存分类代码 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
| 个人防护装备 | Eyeshields, Gloves, type N95 (US) |
Sigma-Aldrich
m.cnreagent.com
