2′-Deoxyuridine 5′-monophosphate disodium salt

产品名称：

42155-08-8
2′-Deoxyuridine 5′-monophosphate disodium salt
dUMP
2'-脱氧尿苷 5'-单磷酸二钠盐

产品介绍：

产品说明

一般描述

2′-Deoxyuridine 5′-monophosphate disodium salt (dUMP) is a substrate for thymidylate synthase and is converted to deoxythymidine monophosphate (dTMP).

应用

2′-Deoxyuridine 5′-monophosphate (dUMP) is used by the enzyme thymidylate synthetase (TS) (EC 2.1.1.45) for the de novo production of dTMP. dUMP is used as the reference substrate in studies of dUMP analogues in potential chemotherapy applications.
2′-Deoxyuridine 5′-monophosphate disodium salt has been used:

in ultraperformance liquid chromatography-tandem mass spectrometry (UPLC/MS/MS) assay
to stimulate proliferation of peripheral blood mononuclear cell (PBMCs) exposed to influenza virus antigen
in thymidylate synthase activity assay Helicobacter pylori

包装

100, 250 mg in poly bottle
1 g in poly bottle

生化/生理作用

2′-Deoxyuridine 5′-monophosphate disodium salt (dUMP) conversion to pyrimidine is inhibited by methotrexate. The inhibition of dUMP to deoxythymidine monophosphate (dTMP) at the methylation step is a key in controlling bacterial and eukaryotic cell growth.

基本信息

线性分子式	C₉H₁₁N₂O₈PNa₂
分子量	352.15
EC 号	255-687-1
MDL编号	MFCD00065282
PubChem化学物质编号	24893787
NACRES	NA.51

产品性质

质量水平	200
等级	Sigma Grade
储存温度	−20℃
SMILES string	[Na].OC1CC(OC1COP(O)(O)=O)N2C=CC(=O)NC2=O
InChI	1S/C9H13N2O8P.Na.H/c12-5-3-8(11-2-1-7(13)10-9(11)14)19-6(5)4-18-20(15,16)17;;/h1-2,5-6,8,12H,3-4H2,(H,10,13,14)(H2,15,16,17);;
InChI key	WXIVKKBDJOCRNB-UHFFFAOYSA-N

安全信息

象形图
警示用语：	Warning
危险声明	H302 - H315 - H319 - H335
预防措施声明	P301 + P312 + P330 - P302 + P352 - P305 + P351 + P338
危险分类	Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官	Respiratory system
储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	dust mask type N95 (US), Eyeshields, Gloves