Tyrphostin AG 825

产品名称：

149092-50-2
Tyrphostin AG 825
Tyrphostin C15
5-[(Benzothiazol-2-yl)thiomethyl]-4-hydroxy-3-methoxybenzylidenecyanoacetamide

产品介绍：

产品说明

应用

Tyrphostin AG 825 has been used to study its effects on iodide uptake in EMT6 cells¹.

生化/生理作用

Tyrphostin AG 825 has been used in combination with hypericin-mediated photodynamic therapy (HY-PDT) for evaluating its therapeutic effects in HER2 overexpressing human breast cancer cells. This study reported that AG 825 combination increased the induction of cell death, HER2 degradation and inhibited colony formation in cancer cells².
EGF receptor tyrosine kinase inhibitor, inactive against IGF-1 Receptor.

特点和优势

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

制备说明

Tyrphostin AG 825 is soluble in DMSO and methanol.

基本信息

经验(实验)分子式	C₁₉H₁₅N₃O₃S₂
分子量	397.47
MDL编号	MFCD01074971
PubChem化学物质编号	329826823
NACRES	NA.77

产品性质

质量水平	200
测定	≥92.5%
形式	powder
溶解性	DMSO: soluble methanol: soluble
储存温度	−20℃
SMILES string	COc1cc(cc(CSc2nc3ccccc3s2)c1O)\C=C(/C#N)C(N)=O
InChI	1S/C19H15N3O3S2/c1-25-15-8-11(6-12(9-20)18(21)24)7-13(17(15)23)10-26-19-22-14-4-2-3-5-16(14)27-19/h2-8,23H,10H2,1H3,(H2,21,24)/b12-6+
InChI key	KXDONFLNGBQLTN-WUXMJOGZSA-N

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Gloves, type N95 (US)