Anti-Glycine Receptor antibody produced in rabbit

产品说明

一般描述

The GLRA1 (glycine receptor α 1) gene is mapped to human chromosome 5q33.1. Glycine receptor is a pentameric Cys-loop ligand-gated ion channel. It is a transmembrane protein, with its five subunits arranged around a central water-filled Cl−selective pore. The protein is expressed all over the nervous system. Each of its subunit contains four transmembrane (TM) segments with an intracellular loop connecting TM3 and TM4, and an extracellular ligand binding domain.

特异性

The antibody recognizes the α1 glycine receptor and cross-reacts with human α2 glycine receptor subunits.

免疫原

synthetic peptide from the amino terminus of the human α1 glycine receptor subunit.

应用

Anti-Glycine Receptor antibody is suitable for western blot analysis of immunoprecipitates of rat spinal cord (lane 2) and human sperm extract in the detection of GlyR in human sperm.

生化/生理作用

Glycine receptors act as excitatory neurotransmitter as well as inhibitory receptor. It plays a central role in acrosome reaction (AR). Mutations in the GLRA1 gene encoding the α1-subunit of the glycine receptor causes startle disease (STHE), also known as hereditary hyperekplexia or congenital stiff-person syndrome.

外形

Lyophilized powder from 5 mM ammonium bicarbonate.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

产品性质