Z-Phe-Ala fluoromethyl ketone

产品名称：

Z-Phe-Ala fluoromethyl ketone
Z-FA-FMK

产品介绍：

产品说明

应用

Z-Phe-Ala fluoromethyl ketone (Z-FA-FMK) has been used as a:

cathepsin inhibitor to study its effects on dendritic cells
papain-like cysteine protease inhibitor to study its effects on cadmium-induced mitochondrial apoptosis
cysteine protease inhibitor to study its effects on the interaction of toll-like receptor 9 (TLR9) with granulin in RAW macrophages

生化/生理作用

Z-Phe-Ala fluoromethyl ketone (Z-FA-FMK) is an inhibitor of cysteine proteases, such as cathepsin B and L. It can also inhibit recombinant effector caspases 2, -3, -6, and -7 and not initiator caspases 8 and -10. Z-FA-FMK plays a role in blocking nuclear factor κ-light-chain-enhancer of activated B cells (NF-κB) transactivation. It exhibits therapeutic effects against rheumatoid arthritis.

基本信息

线性分子式	C₂₁H₂₃N₂O₄F
分子量	386.42
MDL编号	MFCD00883668
PubChem化学物质编号	329774889
NACRES	NA.77

产品性质

质量水平	200
测定	≥90% (TLC)
形式	powder
颜色	white to off-white
溶解性	DMSO or DMF: 20 mM
运输	dry ice
储存温度	−20℃
SMILES string	C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc2ccccc2)C(=O)CF
InChI	1S/C21H23FN2O4/c1-15(19(25)13-22)23-20(26)18(12-16-8-4-2-5-9-16)24-21(27)28-14-17-10-6-3-7-11-17/h2-11,15,18H,12-14H2,1H3,(H,23,26)(H,24,27)/t15-,18-/m0/s1
InChI key	ASXVEBPEZMSPHB-YJBOKZPZSA-N

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Gloves, type N95 (US)