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Anti-B7-H3 (CD276) Antibody, clone MJ8

品牌
Sigma-Aldrich
货号
04-1501
规格纯度
clone MJ8, from rat
参考价格
4848.93 *本价格含增值税费
促销
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数量
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产品名称:
Anti-B7-H3 (CD276) Antibody, clone MJ8
B7 homolog 3, CD276 antigen, CD276 molecule, Costimulatory molecule
产品介绍:

产品说明

一般描述

B7 homolog 3 (B7-H3 or CD276) is a costimulatory molecule belonging to the B7 family that signals through the CD28 family of molecules, including CD28, CTLA4 and ICOS. B7-H3 may be involved in the regulation of T-cell-mediated immune response and may play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis, as well as a role of marker for detection of neuroblastoma cells. B7-H3 may also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses. Isoform 2 is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling. B7-H3 is ubiquitous but not detectable in peripheral blood lymphocytes or granulocytes, and it is weakly expressed in resting monocytes. B7-H3 is expressed in dendritic cells derived from monocytes, epithelial cells of sinonasal tissue, extravillous trophoblast cells and Hofbauer cells of the first trimester placenta and term placenta.

特异性

This antibody recognizes the extracellular domain of B7-H3 (CD276).

免疫原

Epitope: Extracellular Domain
Mouse B7-H3 Ig2a FC fusion protein, consisting of the extracellular domain linked to the Fc portion of mouse IgG2a.

应用

Detect B7-H3 (CD276) using this Anti-B7-H3 (CD276) Antibody, clone MJ8 validated for use in WB, FC, IH.
Research Sub Category
Immunoglobulins & Immunology
Flow Cytometry Analysis: A previous lot was used by an independent laboratory in FC (Osamu, N., et al., 2008).
Immunochistochemistry Analysis: A previous lot was used by an independent laboratory in IH (Osamu, N., et al., 2008).
Research Category
Inflammation & Immunology

质量

Evaluated by Western Blot in human placenta tissue lysate.
Western Blot Analysis: 0.25 µg/mL of this antibody detected BN-H3 on 10 µg of human placenta tissue lysate.

目标描述

~31 kDa observed molecular weight on human lysates corresponds to isoform 2 of B7-H3.

外形

Purified rat monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.
Format: Purified
Protein G Purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

分析说明

Control
Human placenta tissue lysate

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss32160702
NACRESNA.41

产品性质

质量水平100
生物来源rat
抗体形式purified antibody
antibody product typeprimary antibodies
克隆MJ8, monoclonal
species reactivityhuman
species reactivity (predicted by homology)mouse (based on 100% sequence homology)
technique(s)flow cytometry: suitable
immunohistochemistry: suitable
western blot: suitable
同位素/亚型IgG2bκ
NCBI登记号NP_598744.1
UniProt登记号Q8VE98
运输wet ice
Gene Informationhuman ... CD276(80381)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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