产品说明
一般描述
A cell-permeable thienylcarboxamide compound that acts as a potent, ATP-competitive, and highly selective Flt-3 inhibitor (IC50 = 42 nM) with little effect against a panel of 22 other kinases (IC50 ≥3 µM). Shown to exhibit antiproliferative properties against the human acute myelogenous leukemia cell line MV4-11 (IC50 = 340 nM) expressing constitutively active Flt-3.
包装
5 mg in Plastic ampoule
Packaged under inert gas
生化/生理作用
Cell permeable: yes
Target IC50: 42 nM against Flt-3
Reversible: no
Product competes with ATP.
警告
Toxicity: Irritant (B)
其他说明
Patch, R.J., et al. 2006. Bioorg. Med. Chem. Lett.16, 3282.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C18H20N2O4S |
| 分子量 | 360.43 |
| MDL编号 | MFCD00617269 |
产品性质
| 质量水平 | 100 |
| 测定 | ≥98% (HPLC) |
| 形式 | solid |
| manufacturer/tradename | Calbiochem® |
| 储存条件 | OK to freeze protect from light |
| 颜色 | white |
| 溶解性 | DMSO: <4 mg/mL |
| 运输 | ambient |
| 储存温度 | 2-8℃ |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
Sigma-Aldrich
m.cnreagent.com
