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InSolution eIF-2α Inhibitor, Salubrinal-CAS 304475-63-6-Calbiochem

品牌
Sigma-Aldrich
CAS
304475-63-6
货号
324897
规格纯度
The InSolution eIF-2α Inhibitor, Salubrinal, also referenced under CAS 304475-63-6, controls the biological activity of eIF-2α. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applicati
参考价格
3352.28 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
304475-63-6
InSolution eIF-2α Inhibitor, Salubrinal-CAS 304475-63-6-Calbiochem
N-(2,2,2-Tichloro-1-(3-quinolin-8-ylthioureido)ethyl)cinnamamide
产品介绍:

产品说明

一般描述

A cell-permeable and selective inhibitor of the phosphatase complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit α (eIF-2α). Shown to offer protection against ER stress-induced apoptosis (EC50 ~15 µM in PC12 cells stimulated with 750 ng/ml of Tunicamycin (Cat. No. 654380). Prevents HSV replication both in Vero cells (IC50 ~3 µM for reducing plaque formation) in vitro and in a mouse cornea infection model in vivo. The solid form of this compound (Cat. No. 324895) is also available.

包装

5 mg in Glass bottle
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Primary Target
eIF-2α

警告

Toxicity: Irritant (B)

外形

A 50 mM (5 mg/208 µL) solution of eIF-2α Inhibitor, Salubrinal (Cat. No. 324895) in DMSO.

重悬

Following initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C.

其他说明

Boyce, M., et al. 2005. Science307, 935.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C21H17Cl3N4OS
分子量479.81
MDL编号MFCD00548612

产品性质

质量水平100
测定≥95% (HPLC)
形式liquid
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
avoid repeated freeze/thaw cycles
desiccated (hygroscopic)
protect from light
运输dry ice
储存温度−70℃
SMILES stringS=C(NC(NC(/C=C/C1=CC=CC=C1)=O)C(Cl)(Cl)Cl)NC2=CC=CC3=C2N=CC=C3

安全信息

储存分类代码10 - Combustible liquids
WGKWGK 1
闪点(F)188.6 °F - (refers to pure substance)
闪点(C)87 ℃ - (refers to pure substance)

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