产品说明
一般描述
A pyrazolopyrimidine compound that blocks ADP release from the actomyosin complex and acts as a potent, reversible and uncompetitive inhibitor of actin-stimulated ATPase activity of myosin V (Ki = 6.3 and 5.5 µM by single- and double-headed myosin V). Displays excellent selectivity over myosin II and myosin IV (<10% inhibition at 50 µM) and only minimally inhibits the kinase activity of Cdk1/B, CHK1, Plk1, Abl, ERK2, CKII and Aurora-B (<10% inhibition at 100 µM).
包装
5 mg in Glass bottle
Packaged under inert gas
警告
Toxicity: Standard Handling (A)
重悬
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
其他说明
Islam, K., et al. 2010. Angew. Chem. Int. Ed.49, 8484.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
经验(实验)分子式 | C29H26N6O3S |
分子量 | 538.62 |
MDL编号 | MFCD32009180 |
产品性质
质量水平 | 100 |
测定 | ≥95% (HPLC) |
形式 | powder |
manufacturer/tradename | Calbiochem® |
储存条件 | OK to freeze protect from light |
颜色 | pale yellow |
溶解性 | DMSO: 50 mg/mL |
运输 | ambient |
储存温度 | −20℃ |
SMILES string | O=C(C1=CC=CC(SCC2=CC=CC(NC3=NC(NN=C4C5=CC=C(N6CCOCC6)C=C5)=C4C=N3)=C2)=C1)O |
安全信息
储存分类代码 | 11 - Combustible Solids |
WGK | WGK 3 |
闪点(F) | Not applicable |
闪点(C) | Not applicable |
Sigma-Aldrich