REV-ERBα Antagonist, SR8278-Calbiochem

产品说明

一般描述

A cell-permeable REV-ERB antagonist that inhibits REV-ERBα transcriptional repression activity (EC₅₀ = 0.47 µM) in a REV-ERB target gene assay. It is also shown to block the ability of GSK4112 to enhance REV-ERB-&alpha-dependent repression (EC₅₀ = 0.35 µM) in a co-transfection assay. Treatment of HepG2 cells with SR8278 at 10 µM results in a significant increase in the expression of either G6Pase and PEPCK mRNA expression, consistent with its antagonistic role against endogenous heme.

包装

5 mg in Glass bottle
Packaged under inert gas

警告

Toxicity: Regulatory Review (Z)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to months at -20°C.

其他说明

Kojetin, D., et al. 2010, Chem Bio in press

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

产品性质

安全信息