CCT036477, CRT Inhibitor VI, β-Catenin/Tcf Inhibitor VI

Wnt Pathway Inhibitor XI, CCT036477-CAS 305372-78-5-Calbiochem

品牌

Sigma-Aldrich

CAS

305372-78-5

货号

681674

包装型号

5 MG, The Wnt Pathway Inhibitor XI, CCT036477, also referenced under CAS 305372-78-5, controls the biological activity of Wnt Pathway. This small molecule/inhibitor is primarily used for Cancer applications

规格纯度

The Wnt Pathway Inhibitor XI, CCT036477, also referenced under CAS 305372-78-5, controls the biological activity of Wnt Pathway. This small molecule/inhibitor is primarily used for Cancer applications.

参考价格

2147.57 元 *本价格含增值税费

促销

数量

产品名称：

305372-78-5
Wnt Pathway Inhibitor XI, CCT036477-CAS 305372-78-5-Calbiochem
CCT036477, CRT Inhibitor VI, β-Catenin/Tcf Inhibitor VI

产品介绍：

产品说明

一般描述

A cell-permeable indole derivative that acts as an inhibitor of Wnt signaling and exhibits an inhibitory effect in a reporter cell line (IC₅₀ = 4.6 µM) and demonstrates growth inhibition in multiple cancer cell lines, not by altering β-catenin accumulation but by blocking transcription at the β-catenin level. Displays reduced expression of Wnt target genes in myc and survivin-luciferase reporter assays, and exhibits in vivo activity by blocking the development of zebrafish at 20 µM and Xenopus embryos at 75 µM.

包装

5 mg in Glass bottle
Packaged under inert gas

警告

Toxicity: Standard Handling (A)

重悬

Following recontitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Ewan, K., et al. 2010. Cancer Res.70, 5963.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C₂₁H₁₈ClN₃
分子量	347.84
MDL编号	MFCD01831143

产品性质

质量水平	100
测定	≥95% (¹H-NMR)
形式	solid
manufacturer/tradename	Calbiochem^®
储存条件	OK to freeze protect from light
颜色	off-white
溶解性	DMSO: 50 mg/mL
运输	ambient
储存温度	2-8℃

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 2