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Caspase-1 Inhibitor II-CAS 178603-78-6-Calbiochem

品牌
Sigma-Aldrich
CAS
178603-78-6
货号
400012
规格纯度
The Caspase-1 Inhibitor II, also referenced under CAS 178603-78-6, controls the biological activity of Caspase-1. This small molecule/inhibitor is primarily used for Cancer applications.
参考价格
4992.48 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
178603-78-6
Caspase-1 Inhibitor II-CAS 178603-78-6-Calbiochem
IL-1β Converting Enzyme (ICE) Inhibitor II, Ac-YVAD-CMK
产品介绍:

产品说明

一般描述

Interleukin-1β converting enzyme (ICE) is a cysteine protease that cleaves the IL-1β precursor to mature IL-1β. Caspase-1 inhibitor II is a cell-permeable, irreversible inhibitor of Caspase-1, Caspase-4, and Caspase-5. Inhibits CPP32/Apopain at a much higher concentration. Inhibits Fas-mediated apoptosis and acidic sphingomyelinase activation.
A cell-permeable and irreversible inhibitor of caspase-1 (Ki = 760 pM), caspase-4, and caspase-5. Inhibits Fas-mediated apoptosis and acidic sphingomyelinase activation.

包装

5 mg in Plastic ampoule

生化/生理作用

Cell permeable: yes
Target Ki: 760 pM against caspase-1
Product does not compete with ATP.
Reversible: no
Primary Target
caspase-1

警告

Toxicity: Standard Handling (A)

序列

Ac-Tyr-Val-Ala-Asp-CMK

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Brenner, B., et al. 1998. Cell Death Differ. 5, 29.
Garcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.
Hilbi, H., et al. 1998. J. Biol. Chem. 273, 32895.
Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
Schlegel, J., et al. 1996. J. Biol. Chem.271, 1841.
Enari, M., et al. 1995. Nature375, 78.
Walker, N.P.C., et al. 1994. Cell78, 343.
Thornberry, N., et al. 1992. Nature356, 768.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C24H33ClN4O8
分子量540.99
MDL编号MFCD00237124

产品性质

质量水平100
测定≥95% (HPLC)
形式solid
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
desiccated
颜色 white
溶解性DMSO: 5 mg/mL
运输ambient
储存温度−20℃

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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