D609, Potassium Salt-CAS 83373-60-8-Calbiochem

产品说明

一般描述

Selective inhibitor of phosphatidylcholine (PC)-specific phospholipase C (K_i = 5-10 µM). Does not inhibit phosphatidylinositol-specific phospholipase C, phospholipase A, or phospholipase D. Also reported to inhibit LPS-stimulated ERK activation via its inhibitory effect on PLC. Inhibits angiogenesis by preventing the synthesis of basement membrane.
Selective inhibitor of phosphatidylcholine-specific phospholipase C (PC-PLC) (Bacillus cereus, K_i = 5-10 µM). Does not inhibit (up to 50 µM) phosphatidylinositol-specific phospholipase C, phospholipase A₂, and phospholipase D. Inhibitor of the sphingomyelinase activity. Also inhibits angiogenesis by preventing the synthesis of basement membrane (BM).

包装

5 mg in Plastic ampoule

生化/生理作用

Primary Target
pc-specificphopholipase c
Product does not compete with ATP.
Reversible: no
Target K_i: 5-10 µM against phosphatidylcholine (PC)-specific phospholipase C
Cell permeable: no

警告

Toxicity: Standard Handling (A)

制备说明

tissue culture media should be at neutral pH, since product is active only at or slightly below pH 7.0. The compound is inactive at pH 7.4 and above, and it is hydrolyzed below pH 6.0. HEPES buffer should not be used as it renders D609 toxic.

重悬

Material is very labile once in solution (1.5 day half-life in tissue culture medium).

其他说明

Monick, M.M., et al. 1999. J. Immunol. 162, 3005.
Lozanski, G., et al. 1997. Biochem. J.328, 271.
Maragoudakis, M.E., et al. 1993. Kidney Int. 43, 147.
Doppler, C., et al. 1992. AIDS Res. Human Retroviruses8, 245.
Schutze, S., et al. 1992. Cell71, 765.
Sauer, G., et al. 1990. Cancer Lett.53, 97.
Muller-Decker, K. 1989. Biochem. Biophys. Res. Commun.162, 198.
Amtmann, E., et al. 1987. Biochem. Pharmacol.36, 1545.
Sauer, G., et al. 1984. Proc. Natl. Acad. Sci. USA81, 3263.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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