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MMP-2/MMP-3 Inhibitor III, PD166793-CAS 199850-67-4-Calbiochem

品牌
Sigma-Aldrich
CAS
199850-67-4
货号
444284
规格纯度
The MMP-2/MMP-3 Inhibitor III, PD166793, also referenced under CAS 199850-67-4, controls the biological activity of MMP-2/MMP-3. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
参考价格
3124.36 *本价格含增值税费
促销
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数量
-+
产品名称:
199850-67-4
MMP-2/MMP-3 Inhibitor III, PD166793-CAS 199850-67-4-Calbiochem
(S)-2-(4'-Bromo-biphenyl-4-sulfonylamino-3-methylbutyric acid)
产品介绍:

产品说明

一般描述

A cell-permeable biphenylsulfonylvaline compound that acts as a potent inhibitor against MMP-2, -3, and -13 (IC50 = 47, 12, and 8 nM, respectively) and a weaker inhibitor against AMP deaminase (20% inhibition at 0.1 µM), MMP-1, -7, -9, and -14 (IC50 = 6.1, 7.2, 7.9, and 0.24 µM, respectively). Shown to offer therapeutic benefits in vivo in various animal models of heart failure and diabetes.

包装

5 mg in Plastic ampoule

生化/生理作用

Cell permeable: yes
Target IC50: 47, 12, and 8 nM, against MMP-2, -3, and -13, respectively
Product does not compete with ATP.
Reversible: no
Primary Target
MMP-2, -3, and -13

警告

Toxicity: Irritant (B)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

其他说明

Paolocci, N., et al. 2006. J. Pharm. Exp. Ther.317, 506.
Zhou, Y.P., et al. 2005. Diabetes54, 2612.
Peterson, J.T., et al. 2001. Circulation103, 2303.
Spinale, F.G., et al. 1999. Circ. Res.85, 364.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C17H18BrNO4S
分子量412.30

产品性质

质量水平100
测定≥98% (TLC)
形式solid
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
protect from light
颜色 off-white
溶解性DMSO: 40 mg/mL
ethanol: 40 mg/mL
运输ambient
储存温度2-8℃

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 2
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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