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Zardaverine

品牌
Sigma-Aldrich
CAS
101975-10-4
货号
Z3003
规格纯度
phosphodiesterase inhibitor
参考价格
2040.47 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
101975-10-4
Zardaverine
6-(4-Difluoromethoxy-3-methoxyphenyl)-3(2H)-pyridazinone
产品介绍:

产品说明

应用

Zardaverine has been used as a phosphodiesterase inhibitor:

  • to study its effects on human colonic epithelial cells
  • to study its effects on junctional proteins in Sertoli cells
  • to study its effects on phosphodiesterase 3 A (PDE3A) expression in various tumor cells

生化/生理作用

Zardaverine is a derivative of pyridazinone. It shows anti-tumor and anti-proliferative activity in varied cell lines. Zardaverine possesses broncho-dilatory activity and exhibits therapeutic effects against asthma.
Selective inhibitor of phosphodiesterase III/IV (PDE3/4).

基本信息

经验(实验)分子式C12H10F2N2O3
分子量268.22
MDL编号MFCD00867059
PubChem化学物质编号24278784
NACRESNA.77

产品性质

质量水平200
生物来源synthetic (organic)
测定≥98% (HPLC)
形式powder
效能1.1 μM IC50 (for PDE IV)
2.5 μM IC50 (for PDE III)
SMILES stringCOc1cc(ccc1OC(F)F)C2=NNC(=O)C=C2
InChI1S/C12H10F2N2O3/c1-18-10-6-7(2-4-9(10)19-12(13)14)8-3-5-11(17)16-15-8/h2-6,12H,1H3,(H,16,17)
InChI keyHJMQDJPMQIHLPB-UHFFFAOYSA-N
Gene Informationhuman ... PDE3A(5139), PDE3B(5140), PDE4A(5141), PDE4B(5142), PDE4C(5143), PDE4D(5144), PDE5A(8654), PDE7A(5150)
rat ... Pde2a(81743), Pde4a(25638)

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备Eyeshields, Gloves, type N95 (US)

Sigma-Aldrich

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