Zardaverine

产品名称：

101975-10-4
Zardaverine
6-(4-Difluoromethoxy-3-methoxyphenyl)-3(2H)-pyridazinone

产品介绍：

产品说明

应用

Zardaverine has been used as a phosphodiesterase inhibitor:

to study its effects on human colonic epithelial cells
to study its effects on junctional proteins in Sertoli cells
to study its effects on phosphodiesterase 3 A (PDE3A) expression in various tumor cells

生化/生理作用

Zardaverine is a derivative of pyridazinone. It shows anti-tumor and anti-proliferative activity in varied cell lines. Zardaverine possesses broncho-dilatory activity and exhibits therapeutic effects against asthma.
Selective inhibitor of phosphodiesterase III/IV (PDE3/4).

基本信息

经验(实验)分子式	C₁₂H₁₀F₂N₂O₃
分子量	268.22
MDL编号	MFCD00867059
PubChem化学物质编号	24278784
NACRES	NA.77

产品性质

质量水平	200
生物来源	synthetic (organic)
测定	≥98% (HPLC)
形式	powder
效能	1.1 μM IC₅₀ (for PDE IV) 2.5 μM IC₅₀ (for PDE III)
SMILES string	COc1cc(ccc1OC(F)F)C2=NNC(=O)C=C2
InChI	1S/C12H10F2N2O3/c1-18-10-6-7(2-4-9(10)19-12(13)14)8-3-5-11(17)16-15-8/h2-6,12H,1H3,(H,16,17)
InChI key	HJMQDJPMQIHLPB-UHFFFAOYSA-N
Gene Information	human ... PDE3A(5139), PDE3B(5140), PDE4A(5141), PDE4B(5142), PDE4C(5143), PDE4D(5144), PDE5A(8654), PDE7A(5150) rat ... Pde2a(81743), Pde4a(25638)

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Gloves, type N95 (US)