产品说明
一般描述
Fibronectin 1 is a glycoprotein of the extracellular matrix that is coded by FN1 gene. It is expressed in the plasma and at the cell surface. FN1 is mapped to human chromosome 2q35. Proteolytic fragments of fibronectin has a cell binding domain.
应用
Fibronectin Proteolytic Fragment from human plasma has been used in pre adsorbed antibody blocking assay and EC-pericyte tube coassembly.
生化/生理作用
Fibronectin participates in cell adhesion, growth, migration, wound healing, blood coagulation and metastasis. Mutations in FN1 results in glomerulopathy. It plays an important role in cell attachment and spreading, control of cell cytoskeleton, morphology and differentiation. FN1 is also involved in extracellular matrix formation, hemostasis and thrombosis. Proteolytic fragments of fibronectin plays a vital role in mononuclear phagocyte function.
注意
The product should be stored at -20℃.
制备说明
This product is lyophilized from phosphate buffered saline with sucrose as a cryoprotectant. The source material has tested negative for antibody to HIV, HCN, and HBsAg. It is soluble in water at 0.5 mg/mL and yields a clear to slightly hazy solution.
基本信息
| MDL编号 | MFCD00131062 |
| eCl@ss | 42020141 |
| NACRES | NA.75 |
产品性质
| 质量水平 | 200 |
| 生物来源 | human plasma |
| 测定 | >90% (SDS-PAGE) |
| 形式 | lyophilized powder |
| 分子量 | 70 kDa |
| 包装 | pkg of 0.5 mg |
| technique(s) | cell culture | mammalian: suitable |
| 杂质 | HIV and HBsAg, source material tested negative Small proteolytic fragments, may contain traces |
| 溶解性 | water: soluble ≥0.500 mg/mL, clear to slightly hazy, colorless |
| UniProt登记号 | P02751 |
| 运输 | ambient |
| 储存温度 | −20℃ |
| Gene Information | human ... FN1(2335) |
安全信息
| 象形图 |  |
| 警示用语： | Warning |
| 危险声明 | H315 - H319 - H335 |
| 预防措施声明 | P302 + P352 - P305 + P351 + P338 |
| 危险分类 | Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3 |
| 靶器官 | Respiratory system |
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
