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Interleukin-10 from mouse

品牌
Sigma-Aldrich
货号
I3019
规格纯度
>97% (SDS-PAGE), recombinant, expressed in E. coli, suitable for cell culture
参考价格
3764.03 *本价格含增值税费
促销
服务
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数量
-+
产品名称:
Interleukin-10 from mouse
IL-10
产品介绍:

产品说明

应用

Interleukin-10 from mouse has been used as a standard in ELISA (enzyme-linked immunosorbent assay) cytokine assay.

生化/生理作用

Interleukin-10 regulates lymphoid and myeloid cell functions. It blocks the activation of cytokine synthesis and several accessory functions of macrophages. IL-10 enhances cytotoxic T cell development and co-stimulates B cell differentiation and Ig secretion. IL-10 regulates angiogenesis by inducing cell-type dependent expression of either angiogenic or angiostatic factors.
Interleukin-10 is an important regulator of the functions of lymphoid and myeloid cells. IL-10 can block the activation of cytokine synthesis and several accessory functions of macrophages. Human and mouse IL-10 share a 73% sequence homology. However, human IL-10 acts on both human and mouse target cells, while mouse IL-10 has species-specific activity. In mouse, the cellular sources of IL-10 consist of Th2 cells, activated fetal thymocytes, macrophages, keratinocytes, LY-1+ (CD5+), and normal B cells. In human, the cellular sources of IL-10 consist of CD4+ T cells and T cell clones, thymocytes, B cells, B cell lymphomas, macrophages, mast cell lines and keratinocytes. IL-10 stimulates the growth of stem cells, mast cells and thymocytes. IL-10 enhances cytotoxic T cell development, and co-stimulates B cell differentiation and Ig secretion. IL-10 regulates angiogenesis by inducing the cell-type dependent expression of either angiogenic or angiostatic factors.

外形

Lyophilized from a 0.2 μm filtered solution in PBS, pH 7.4 with 50 μg BSA per 1 μg as a carrier protein

分析说明

The biological activity of IL-10 is determined in a cell proliferation assay using MC/9 cells.

基本信息

MDL编号MFCD00212207

产品性质

质量水平200
生物来源mouse
重组expressed in E. coli
测定>97% (SDS-PAGE)
形式lyophilized powder
效能0.01-1.50 ng/mL EC50
分子量 ~18 kDa
包装pkg of 5 μg
technique(s)cell culture | mammalian: suitable
杂质 endotoxin, tested
UniProt登记号P18893
运输dry ice
储存温度−20℃
Gene Informationmouse ... Il10(16153)

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Sigma-Aldrich

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