Anti-TRF2 Antibody, clone 4A794

产品说明

一般描述

TRF2 is a ubiquitously expressed protein that is implicated in the control of telomere length. TRF2, like TRF1, contains a Myb-related DNA binding motif. It binds to duplex TTAGGG repeats and is localised to all human telomeres in metaphase chromosomes. TRF2 is thought to protect chromosome ends by maintaining the correct structure at telomere termini. The use of mutant forms of TRF2 has implicated a role for TRF2 in the prevention of senescence in primary human cells. Recently, it has been shown that inhibition of TRF2 resulted in apoptosis in a subset of mammalian cell types. TRF2 is overexpressed in a number of human tumors and overexpression of TRF2 has been shown to be oncogenic in a mouse model of carcinogenesis.

特异性

Recognizes TRF2.

免疫原

His-tagged, fusion-protein, corresponding to full-length TRF2 (Telomeric Repeat binding Factor 2), expressed in baculovirus

应用

Research Sub Category
Cell Cycle, DNA Replication & Repair
Research Category
Epigenetics & Nuclear Function
Anti-TRF2 Antibody, clone 4A794 is a Mouse Monoclonal Antibody for detection of TRF2 also known as Telomeric repeat-binding factor 1 & has been tested in ICC & WB.

质量

routinely evaluated by immunoblot on RIPA lysate of human Jurkat cells, HeLa nuclear extract, or rat L6 RIPA cell lysate

目标描述

66 kDa

外形

Format: Purified
Protein G Purified mouse IgG1 in PBS with 0.05% sodium azide.
Protein G Purified

储存及稳定性

Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

分析说明

Control
Positive Control Included: Jurkat cell lysate (12-303)

法律信息

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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