Caspase Inhibitor

产品名称：

Caspase Inhibitor
caspase 6 inhibitor
Ac-AEVD-CHO
caspase 8 inhibitor

产品介绍：

产品说明

Amino Acid Sequence

Ac-Ala-Glu-Val-Asp-al

一般描述

Currently, there are 13 caspases recognized in mammals. Caspases are classified as initiators and effectors. Caspase 8 belongs to the class of initiators. It possesses a prodomain at the terminal and contains the death effector domain which serves as protein-protein interaction motif for caspase 8. With respect to substrate specificity, caspase 8 is classified as a member of group III. It specifically recognizes the (I/L/V) EXD sequence on the substrate.

应用

Caspase Inhibitor has been used to study the specificity of the CIL-1 (desglucoanagalloside B) interaction with the caspase 3/7 system.

生化/生理作用

The peptide Ac-Ala-Glu-Val-Asp-al, or Ac-AEVD-CHO, is an inhibitor of Group III caspases. It acts upon caspases-6, 8, 9, and 10, with particular effectiveness on caspase-6 and caspase-8. The use of Ac-AEVD-CHO in several apotosis studies has been reported.

基本信息

经验(实验)分子式	C₁₉H₃₀N₄O₉
分子量	458.46
NACRES	NA.32

产品性质

测定	≥95% (HPLC)
形式	lyophilized
组成	Peptide Content, ≥80%
储存条件	protect from light
储存温度	−20℃
Gene Information	human ... CASP10(843), CASP6(839), CASP8(841), CASP9(842)

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable