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Monoclonal Anti-CDK4 antibody produced in mouse

品牌
Sigma-Aldrich
货号
C8218
规格纯度
clone DCS-31, ascites fluid
参考价格
7376.44 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
Monoclonal Anti-CDK4 antibody produced in mouse
产品介绍:

产品说明

一般描述

Cdk4 exists, in part, as a multi-protein complex with a D-type cyclin, proliferating cell nuclear antigen (PCNA) and a protein inhibitor, p21Cip1. Cdk4 associates separately with p16, particularly in cells lacking a functional retinoblastoma protein.
Monoclonal Anti-Cdk4 (mouse IgG2a isotype) is derived from the DCS-31 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse. Cyclin-dependent kinase 4 is localized in human chromosome 12q14.1.

特异性

The antibody reacts specifically with Cdk4 and does not recognize other Cdk types.

免疫原

recombinant human Cdk4 protein

应用

Monoclonal Anti-Cdk4 antibody was used in:

  • immunoprecipitation of human melanoma cell line.
  • immunofluorescence of fibrosarcoma cells.
  • western blot analysis
  • immunofluorescence
  • immunohistochemistry

生化/生理作用

In association with cyclins, cyclin-dependent kinases (CDKs) forms active kinase complexes which is responsible for regulating cell cycle progression in eukaryotic cells. Within the complexes, the CDKs serves a catalytic protein kinase activity. This catalytic activity is regulated by two mechanisms: protein phosphorylation and association of regulatory subunits.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号MFCD00282839
NACRESNA.41

产品性质

质量水平200
生物来源mouse
偶联物unconjugated
抗体形式ascites fluid
antibody product typeprimary antibodies
克隆DCS-31, monoclonal
分子量antigen 33 kDa
包含15 mM sodium azide
species reactivityhuman, rat, mouse
technique(s)immunocytochemistry: suitable
immunoprecipitation (IP): suitable
microarray: suitable
western blot: 1:1,000 using a cultured human tumor cell line extract
同位素/亚型IgG2a
UniProt登记号P11802
运输dry ice
储存温度−20℃
Gene Informationhuman ... CDK4(1019)
mouse ... Cdk4(12567)
rat ... Cdk4(94201)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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