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Ferutinin

品牌
Sigma-Aldrich
CAS
41743-44-6
货号
SML1609
包装型号
规格纯度
≥98% (HPLC)
参考价格
1746.67 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
41743-44-6
Ferutinin
Ferutinine
4-Hydroxy-benzoic acid (3R,3aS,4S,8aR)-1,2,3,3a,4,5,8,8a-octahydro-3-hydroxy-6,8a-dimethyl-3-(1-methylethyl)-4-azulenyl ester
Tefestrol
4-Oxy-6-(4-oxybenzoyloxy)dauc-8,9-en
产品介绍:

产品说明

一般描述

Ferutinin, a daucane phytoestrogen, is found in the Ferula genus. It is a natural terpenoid and a calcium ionophore.

包装

5 mg in glass bottle

生化/生理作用

Ferutinin can suppress tumor development without causing systemic toxicity in various tumor cells and animal cancer models. It possesses estrogenic properties and a protective role against uterine carcinoma. Ferutinin exhibits anti-cancer action in estrogen-dependent breast cancer cells.
Ferutinin is a strong agonist for estrogen receptor (ER)α and agonist/antagonist for Erβ with IC50 values of 33.1 nM for ERα and 180.5 nM for Erβ. It has been shown to have both ionophoretic and apoptotic properties. It increases calcium permeability in the lipid bilayer and has been shown to improve bone regeneration in a rat study. It caused significant regression in tumor size in a mouse colon cancer model.

基本信息

经验(实验)分子式C22H30O4
分子量358.47
PubChem化学物质编号329825495
NACRESNA.77

产品性质

质量水平100
测定≥98% (HPLC)
形式powder
储存条件protect from light
颜色 white to beige
储存温度2-8℃
SMILES stringCC1=CC[C@](CC[C@@]2(O)C(C)C)(C)[C@@]2([H])[C@@H](OC(C3=CC=C(O)C=C3)=O)C1
InChI1S/C22H30O4/c1-14(2)22(25)12-11-21(4)10-9-15(3)13-18(19(21)22)26-20(24)16-5-7-17(23)8-6-16/h5-9,14,18-19,23,25H,10-13H2,1-4H3/t18-,19+,21-,22+/m0/s1
InChI keyCYSHNJQMYORNJI-YUVXSKOASA-N

安全信息

危险声明H413
危险分类Aquatic Chronic 4
储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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