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ML-9

品牌
Sigma-Aldrich
CAS
105637-50-1
货号
C1172
规格纯度
≥99% (TLC), powder
参考价格
1612.05 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
105637-50-1
ML-9
1-(5-Chloronaphthalene-1-sulfonyl)-1H-hexahydro-1,4-diazepine hydrochloride
产品介绍:

产品说明

应用

ML-9 has been used in the inhibition of myosin light chain kinase (MLCK) and non-muscle myosin IIA (NMIIA) in human corneal epithelial cells and HeLa cells.

包装

5 mg in glass bottle

生化/生理作用

ML-9 is myosin light chain kinase inhibitor. It inhibits insulin-induced translocation of glucose transporters GLUT4 and GLUT1 in a dose-dependent manner. ML-9 also inhibits agonist-induced Ca2+ entry into endothelial cells and catecholamine secretion in intact and permeabilized chromaffin cells. ML-9 promotes cell death in cancer cells by triggering accumulation of autophagic vacuoles. ML-9 impacts phosphorylation of myosin light chain kinase and alters trabecular meshwork shape and decreases intraocular pressure in rabbit eyes.

特点和优势

This compound is featured on the Ca/CaMKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

基本信息

线性分子式C15H17N2O2SCl · HCl
分子量361.29
MDL编号MFCD00065525
PubChem化学物质编号24278297
NACRESNA.77

产品性质

质量水平200
生物来源synthetic (organic)
测定≥99% (TLC)
形式powder
颜色 white
溶解性ethanol: 10 mg/mL
储存温度2-8℃
SMILES stringCl.Clc1cccc2c(cccc12)S(=O)(=O)N3CCCNCC3
InChI1S/C15H17ClN2O2S.ClH/c16-14-6-1-5-13-12(14)4-2-7-15(13)21(19,20)18-10-3-8-17-9-11-18;/h1-2,4-7,17H,3,8-11H2;1H
InChI keyZNRYCIVTNLZOGI-UHFFFAOYSA-N
Gene Informationhuman ... SLC2A1(6513), SLC2A4(6517)

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备Eyeshields, Gloves, type N95 (US)

Sigma-Aldrich

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