MJ33 锂盐

产品名称：

199106-13-3
MJ33 lithium salt
1-Hexadecyl-3-(trifluoroethyl)-sn-glycero-2-phosphomethanol lithium
MJ33 锂盐

产品介绍：

产品说明

应用

MJ33 lithium salt has been used as a peroxiredoxin VI (Prdx6) inhibitor:

to study its specific Prdx6 peroxidase activity in vitro and in breast cancer cell line (MCF-7) cell lysates
to study its effects on a mouse model of acute lung injury associated with exposure to hyperoxia
to study its potential use as a therapeutic agent

包装

5 mg in glass bottle

生化/生理作用

MJ33 acts as a non-toxic and potent inhibitor of agonist-induced activation of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase type 2 (NOX2). It also prevents lung injuries associated with lung inflammation in mice. MJ33 is a fluorinated lipid analog, which blocks the enzyme by mimicking the transition state of the substrate.
Novel, active site directed, specific, competitive and reversible inhibitor of phospholipase A₂ (PLA₂).

基本信息

经验(实验)分子式	C₂₂H₄₃F₃O₆PLi
分子量	498.48
MDL编号	MFCD03787978
PubChem化学物质编号	24278549
NACRES	NA.77

产品性质

质量水平	100
测定	≥90% (NMR)
形式	powder
颜色	white to beige
溶解性	H₂O: ≥5 mg/mL (warmed at 60 ℃)
储存温度	2-8℃
SMILES string	CCCCCCCCCCCCCCCCOCC(COCC(F)(F)F)OP(OC)([O-])=O.[Li+]
InChI	1S/C22H44F3O6P.Li/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-29-18-21(31-32(26,27)28-2)19-30-20-22(23,24)25;/h21H,3-20H2,1-2H3,(H,26,27);/q;+1/p-1
InChI key	GDLMLQJISATCEL-UHFFFAOYSA-M

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Gloves, type N95 (US)