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(R)-ZINC-3573

品牌
Sigma-Aldrich
货号
SML1699
规格纯度
≥98% (HPLC)
参考价格
1562.86 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
(R)-ZINC-3573
(R)-ZINC72453573
(R)-N,N-Dimethyl-1-(5-phenylpyrazolo[1,5-a]pyrimidin-7-yl)-3-pyrrolidinamine
产品介绍:

产品说明

包装

5, 25 mg in glass bottle

生化/生理作用

(R)-ZINC-3573 is a selective agonist probe of the orphan receptor Mas-related G-protein coupled receptor member X2 (MRGPRX2), a G-protein coupled receptor (GPCR) selectively expressed in mast cells and dorsal root and trigeminal ganglia primary sensory neurons of primates. Lack of selective and potent probes has made it difficult to determine MRGPRX2 funtion. (R)-ZINC-3573 was shown to be a potent and selective agonist with an EC50 value of 760 nM for MRGPRX2 and little activity for MRGPRX1 or over 350 other GPCRs and 97 kinases tested. (R)-ZINC-3573 activates endogenous MRGPRX2 expressed in a human mast cell line and induced degranulation and calcium release.

基本信息

经验(实验)分子式C18H21N5
分子量307.39

产品性质

质量水平100
测定≥98% (HPLC)
形式powder
颜色 white to beige
溶解性DMSO: 5 mg/mL, clear (warmed)
储存温度2-8℃
SMILES stringCN([C@H](CC1)CN1C2=CC(C3=CC=CC=C3)=NC4=CC=NN24)C

安全信息

象形图GHS07
警示用语:Warning
危险声明H315
危险分类Skin Irrit. 2
储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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