7ACC2

产品名称：

1472624-85-3
7ACC2
7-[Benzyl(methyl)amino]-2-oxo-2H-chromene-3-carboxylic acid
7-Aminocarboxycoumarin 2
7-ACC2
7-[Methyl(phenylmethyl)amino]-2-oxo-2H-1-benzopyran-3-carboxylic acid
7-(N-Benzyl-N-methylamino)-2-oxo-2H-chromene-3-carboxylic acid

产品介绍：

产品说明

生化/生理作用

7ACC2 is a monocarboxylate transporters MCT1 & MCT4 (SLC16A1 & SLC16A3) inhibitor that affects lactate uptake-dependent cancer growth in cultures (uptake/proliferation IC50 = 59/220 nM; MCT1/4-expressing SiHA cervix cancer in the absence of glucose) and in vivo (3 mg/kg/day i.p.; SiHa, HCT116, MCF-7 in mice), without affecting lactate efflux or the survival of highly glycolytic HL-60 (MCT1) or MDA-MB231 (MCT4) cancer cells. Unlike the MCT1/2 inhibitor AR-C155858, 7ACC2 does not block MCT1-mediated uptake of the anti-cancer drug 3-bromopyruvate (3-BP).

基本信息

经验(实验)分子式	C₁₈H₁₅NO₄
分子量	309.32
MDL编号	MFCD28167835

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 2 mg/mL, clear
储存温度	2-8℃
SMILES string	O=C(O)C1=CC2=C(C=C(C=C2)N(C)CC3=CC=CC=C3)OC1=O

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable