产品说明
包装
5, 25 mg in glass bottle
生化/生理作用
BF-170 is a new probe for neurofibrillary tangles (tau fibrils). It exhibits greater binding affinity to tau than to Aβ fibrils, EC50 = 221 nM vs. EC50 = 786 nM (Ki for Aβ > 5,000 nM). BF-170 demonstrates fast clearance from the brain; clearly visualizes neurofibrillary tangles, neuropil threads, and paired helical filament-type neuritis. BF-70 may become one of the candidate compounds for in vivo imaging of tau pathology associated with Alzheimer′s disease and is a useful tool in distinguishing among tau and Aβ fibrils specifically in AD.
注意
Product is air sensitive, store under inert gas.
基本信息
| 经验(实验)分子式 | C15H12N2 · HCl |
| 分子量 | 256.73 |
| MDL编号 | MFCD08705340 |
| PubChem化学物质编号 | 24891766 |
| NACRES | NA.77 |
产品性质
| 质量水平 | 100 |
| 测定 | ≥98% (HPLC) |
| 形式 | solid |
| 储存条件 | desiccated protect from light under inert gas |
| 颜色 | orange |
| 溶解性 | H2O: 10 mg/mL |
| 储存温度 | −20℃ |
| SMILES string | Cl[H].Nc1ccc(cc1)-c2ccc3ccccc3n2 |
| InChI | 1S/C15H12N2.ClH/c16-13-8-5-12(6-9-13)15-10-7-11-3-1-2-4-14(11)17-15;/h1-10H,16H2;1H |
| InChI key | UYYPMQOFLJHJAW-UHFFFAOYSA-N |
安全信息
| 象形图 |   |
| 警示用语： | Danger |
| 危险声明 | H302 - H315 - H318 - H335 |
| 预防措施声明 | P280 - P301 + P312 + P330 - P302 + P352 - P305 + P351 + P338 + P310 |
| 危险分类 | Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3 |
| 靶器官 | Respiratory system |
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
| 个人防护装备 | dust mask type N95 (US), Eyeshields, Faceshields, Gloves |
Sigma-Aldrich
m.cnreagent.com
