Cilengitide trifluoroacetic acid salt

产品名称：

188968-51-6
Cilengitide trifluoroacetic acid salt
Cyclo(L-arginylglycyl-L-a-aspartyl-D-phenylalanyl-N-methyl-L-valyl), 2,2,2-trifluoroacetate
EMD 121974
NSC 707544
c(RGDF(NMe)V)
2,2,2-trifluoroacetate

产品介绍：

产品说明

应用

Cilengitide trifluoroacetic acid salt has been used as an inhibitor of integrin αvβ5.

包装

5, 25 mg in glass bottle

生化/生理作用

It exhibits antitumor activity in glioblastoma multiforme tumors. Integrins are heterodimers of α and β chain. They are transmembrane receptors which are responsible for cell-to-cell and cell-extracellular matrix interactions. They control tumor angiogenesis, invasion and migration.
Cilengitide is a vascular targeting agent (VTA) that acts as an integrin antagonist. Cilengitide is a cyclized Arg-Gly-Glu(RGD)-containing pentapeptide that selectively blocks activation of the αvβ3 and αvβ5 integrins.

基本信息

经验(实验)分子式	C₂₇H₄₀N₈O₇ · xC₂HF₃O₂
分子量	588.66 (free base basis)

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	H₂O: 20 mg/mL, clear
储存温度	−20℃

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3