产品说明
包装
5, 25 mg in glass bottle
生化/生理作用
Eicosapentaenoyl ethanolamide (EPEA) is a lipid mediator that has been found to suppress lifespan extension resulting from dietary restriction in C. elegans and also to have antiproliferative and anti-inflammatory actions. In C. elegans, it is believed to act as a metabolic signal that couples nutrient availability with growth and lifespan. EPEA is a member of the N-acylethanolamines (NAEs), lipid-derived signaling molecules that include the mammalian endocannabinoid arachidonoyl ethanolamide (AEA). In mammals, NAEs are believed to act primarily through cannabinoid receptors, although they can also interact with a variety of other targets, and EPEA has been shown to act as a CB1 and CB2 receptor agonist. However, C. elegans does not possess clear orthologues of the mammalian cannabinoid receptors which suggests that there are unidentified NAE receptors in nematodes that are possibly conserved mediators of NAE signaling.
其他说明
Light and air sensitive; store in a freezer.
基本信息
| 经验(实验)分子式 | C22H35NO2 |
| 分子量 | 345.52 |
| MDL编号 | MFCD22416528 |
| PubChem化学物质编号 | 329825384 |
| NACRES | NA.77 |
产品性质
| 质量水平 | 100 |
| 测定 | ≥98% (HPLC) |
| 形式 | solution |
| drug control | regulated under CDSA - not available from sigma-aldrich Canada |
| 储存条件 | protect from light under inert gas |
| 浓度 | 5 mg/mL in absolute ethanol |
| 颜色 | light yellow |
| 储存温度 | −20℃ |
| SMILES string | CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCC(=O)NCCO |
| InChI | 1S/C22H35NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-22(25)23-20-21-24/h3-4,6-7,9-10,12-13,15-16,24H,2,5,8,11,14,17-21H2,1H3,(H,23,25)/b4-3-,7-6-,10-9-,13-12-,16-15- |
| InChI key | OVKKNJPJQKTXIT-JLNKQSITSA-N |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
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